Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-c-Jun Rabbit mAb [19A48]
抗c-Jun兔单克隆抗体 [19A48]
Cat. No.
A52079
Clone No. 19A48
Synonymsc-Jun, p39, v-jun sarcoma virus oncogene homolog
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
36 kDa
Observed MW
43 kDa
Clonality
Monoclonal
Clone No.
19A48
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
JUN
Protein Name
Jun proto-oncogene, AP-1 transcription factor subunit
Background
c-Jun (Proto-oncogene protein c-Jun) belongs to AP-1 transcription-factor family and mediates transcriptional control over cell proliferation, apoptosis and stress responses. c-Jun heterodimerizes with c-Fos to assemble AP-1 complex, which recognizes AP-1 cis-elements on gene promoters and governs transcription of broad downstream targets. Mitogens, cytokines and oxidative stress induce c-Jun up-regulation to modulate cell proliferation, migration, differentiation and apoptosis. Constitutive c-Jun activation drives oncogenesis, invasion and metastasis and mediates tumor-microenvironment signaling. As a major downstream effector of MAPK cascades, c-Jun is widely investigated in tumor, inflammation and cellular-stress-pathway researches.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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