Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-c-Jun (phospho Ser63) Rabbit mAb [17E80]
抗c-Jun (phospho Ser63)兔单克隆抗体 [17E80]
Cat. No.
A52080
Clone No. 17E80
Synonymsc-Jun (phospho Ser63), p-c-Jun(Ser63), c-Jun, p39, v-jun
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
36 kDa
Observed MW
48 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
17E80
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
JUN
Protein Name
c-Jun (phospho Ser63)
Background
c-Jun (Phospho-Ser63) belongs to AP-1 transcription-factor family and executes stress-triggered transcriptional activation. Ser63 is a critical N-terminal phosphorylation site mainly modified by JNK kinase. Under resting conditions, c-Jun Ser63 phosphorylation remains low. Upon JNK-pathway activation triggered by cytokines, DNA damage or oxidative stress, nuclear-translocated JNK catalyzes Ser63 phosphorylation to markedly boost c-Jun trans-activation capacity, driving pro-inflammatory and pro-proliferative gene programs for stress response, apoptosis and malignant transformation. Phospho-Ser63 level directly reports JNK-c-Jun cascade activity and is widely measured for MAPK/JNK pathway evaluation in inflammatory and oncogenic-signaling researches.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:100-1:500
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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