Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-COX2 Rabbit mAb [66B63]
抗COX2兔单克隆抗体 [66B63]
Cat. No.
A52086
Clone No. 66B63
SynonymsCOX2, COX-2, PGHS-2, Prostaglandin-endoperoxide synthase 2, HTCP1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
69 kDa
Observed MW
75 kDa
Clonality
Monoclonal
Clone No.
66B63
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PTGS2
Protein Name
Cyclooxygenase-2
Background
COX2 (Cyclooxygenase-2, PTGS2) belongs to cyclooxygenase family and mediates pro-inflammatory prostaglandin biosynthesis. COX2 maintains minimal basal expression and is strongly transcriptionally induced by pro-inflammatory cytokines, LPS and tumor-microenvironment cues. COX2 catalyzes arachidonic-acid conversion into prostaglandin mediators to drive inflammation, pain response and angiogenesis. In tumor tissues, COX2 over-expression promotes cell proliferation, suppresses anti-tumor immunity and facilitates neovascularization to accelerate tumor progression. COX2 constitutes a major target for non-steroidal anti-inflammatory drugs. It is widely used in inflammatory-model, oncogenesis and pharmacological-mechanism researches.
Localization
Endoplasmic Reticulum
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:500
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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