Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-ATF-4 Rabbit mAb [11H59]
抗ATF-4兔单克隆抗体 [11H59]
Cat. No.
A52088
Clone No. 11H59
SynonymsATF-4, C/EBP-homologous transcription factor, bZIP family protein, CREB2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
38 kDa
Observed MW
49 kDa
Clonality
Monoclonal
Clone No.
11H59
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
ATF4
Protein Name
Activating transcription factor-4
Background
ATF-4 (Activating transcription factor 4) belongs to bZIP transcription-factor family and governs transcriptional responses to ER stress and amino-acid deprivation. Under homeostatic conditions, ATF-4 protein is kept at low abundance. Upon ER stress, amino-acid shortage or oxidative insult, eIF2α phosphorylation selectively enhances ATF-4 translation. Nuclear-translocated ATF-4 binds CRE/ATF cis-elements and modulates target-gene networks for amino-acid transport, oxidative-stress defence and ER-homeostasis maintenance. Sustained ATF-4 activation triggers CHOP-dependent apoptosis. ATF-4 contributes to tumor metabolism, drug resistance and metabolic disorders. It acts as a stress-pathway hub for ER-stress, nutrient-sensing and tumor-biology investigations.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:200
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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