Anti-Ctip2 Rabbit mAb [88D07]

Protein A affinity purification

B-cell CLL/lymphoma 11B

Ctip2 (Bcl11b) belongs to the C2H2 zinc finger transcription factor family, and functions in cell differentiation, immune cell development and neuronal fate regulation. Ctip2 is indispensable during T lymphocyte development, regulating thymic T cell differentiation, maturation and T cell subset fate determination. It also participates in the differentiation of neuronal subtypes in the cerebral cortex and controls the axonal projection pattern of projection neurons. Dysregulation of Ctip2 function leads to blocked T cell development and immunodeficiency, and can also trigger abnormal nervous system development. Aberrant Ctip2 expression is observed in some tumors, which participates in the regulation of malignant phenotypes of tumor cells. This target is widely used in studies of immune development, neurogenesis and tumor biological mechanisms.

Nucleus