Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cyclin D1 Rabbit mAb [03G85]
抗Cyclin D1兔单克隆抗体 [03G85]
Cat. No.
A52092
Clone No. 03G85
SynonymsCyclin-D1, Cyclin D1, PRAD1, bcl-1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
34 kDa
Observed MW
36 kDa
Clonality
Monoclonal
Clone No.
03G85
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CCND1
Protein Name
Cyclin-D1
Background
Cyclin D1 is a G1-phase cyclin family member promoting G1-phase progression and cell proliferation. Induced by growth-factor signalling, Cyclin D1 binds and activates CDK4/6, phosphorylates Rb tumour-suppressor protein and liberates E2F transcription factors to drive G1-checkpoint passage toward S-phase. Beyond kinase-dependent function, Cyclin D1 translocates into nucleus to directly modulate transcription. CCND1 amplification, chromosomal translocation or impaired protein degradation lead to aberrant Cyclin D1 accumulation and malignant proliferation, frequently observed in solid and haematological malignancies. Cyclin D1 serves as a tumour-proliferation marker for cell-cycle, oncogenesis and targeted-drug-mechanism researches.
Localization
Cytoplasm, Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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