Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cyclin E1 Rabbit mAb [83F12]
抗Cyclin E1兔单克隆抗体 [83F12]
Cat. No.
A52093
Clone No. 83F12
SynonymsCyclin-E1, Cyclin E1, CCNE1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
47 kDa
Observed MW
47 kDa
Clonality
Monoclonal
Clone No.
83F12
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CCNE1
Protein Name
Cyclin-E1
Background
Cyclin E1 is a G1/S-phase cyclin controlling G1/S transition and DNA-replication initiation. Cyclin E1 binds and activates CDK2 to form CyclinE1-CDK2 complex. It phosphorylates Rb and replication-associated substrates to drive cells across G1/S restriction point and trigger S-phase DNA replication. Cyclin E1 abundance is tightly controlled temporally and degraded via ubiquitination upon S-phase onset. Aberrant Cyclin E1 overexpression provokes cell-cycle deregulation and genomic instability, strongly correlating with oncogenesis and poor clinical prognosis. Cyclin E1 is a central cell-cycle target widely studied in tumour proliferation, genome-stability and drug-intervention mechanistic researches.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:400-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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