Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cytokeratin 18 Rabbit mAb [10F65]
抗Cytokeratin 18兔单克隆抗体 [10F65]
Cat. No.
A52096
Clone No. 10F65
SynonymsCytokeratin 18, CK-18, K18, CK18, type II cytokeratin 18
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
48 kDa
Observed MW
48 kDa
Clonality
Monoclonal
Clone No.
10F65
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
KRT18
Protein Name
Keratin-18
Background
Cytokeratin 18 (CK18) belongs to type-I intermediate-filament family and provides cytoskeletal support for simple epithelia. Expressed in diverse simple epithelia including gastrointestinal, hepatic and pulmonary glandular cells, CK18 heterodimerizes with CK8 to form keratin intermediate filaments, maintaining glandular-epithelial morphology and mechanical resilience. Upon apoptosis, CK18 is proteolytically cleaved into characteristic fragments used for epithelial-cell apoptosis detection. CK18 is a classic glandular-epithelium marker; epithelial-derived tumours commonly retain CK18 expression. Circulating CK18 fragments serve as auxiliary markers for tissue injury. It is widely adopted for epithelial-tissue pathology, glandular-tumour subtyping and epithelial-apoptosis researches.
Localization
Cytoskeleton
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:2000-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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