Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cytokeratin 8 Rabbit mAb [17H52]
抗Cytokeratin 8兔单克隆抗体 [17H52]
Cat. No.
A52101
Clone No. 17H52
SynonymsCytokeratin 8, CK-8, K8, CK8, type I cytokeratin 8
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
54 kDa
Observed MW
54 kDa
Clonality
Monoclonal
Clone No.
17H52
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
KRT8
Protein Name
Keratin-8
Background
Cytokeratin 8 (CK8) belongs to type-II intermediate-filament family and provides cytoskeletal support for simple glandular epithelia. Widely expressed in simple glandular cells from gastrointestinal tract, liver and lung, CK8 heterodimerizes with CK18 to build keratin intermediate-filament networks, preserving glandular-epithelial architecture and mechanical resistance. CK8 deficiency or dysfunction aggravates epithelial injury and contributes to hepatic and intestinal pathological processes. Most glandular-origin tumours retain CK8 expression.
Localization
Cytoskeleton
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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