Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-DRP1 (phospho Ser616) Rabbit mAb [09E21]
抗DRP1 (phospho Ser616)兔单克隆抗体 [09E21]
Cat. No.
A52102
Clone No. 09E21
SynonymsDRP1 (phospho Ser616), p-DRP1(Ser616), Dynamin-1-like protein, Drp1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
82 kDa
Observed MW
82 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
09E21
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
DNM1L
Protein Name
DRP1 (phospho Ser616)
Background
Phospho-DRP1 (Ser616) is an activated post-translational modification form of dynamin-related protein 1 (DRP1). DRP1, encoded by the DNM1L gene, is a GTPase belonging to the dynamin superfamily and serves as a master regulator of mitochondrial and peroxisomal fission. The Ser616 residue is a key activating phosphorylation site primarily mediated by Cdk1/cyclin B. Phosphorylation at Ser616 significantly enhances DRP1 GTPase activity, promotes DRP1 oligomerization and recruitment to mitochondrial fission sites, drives mitochondrial fragmentation, and participates in cell cycle progression, mitochondrial quality control, apoptosis and autophagic metabolism. Excessive Ser616 phosphorylation causes mitochondrial over-fragmentation, triggering oxidative stress damage, metabolic dysfunction and abnormal apoptosis, which is closely associated with neurodegenerative diseases, tumor proliferation and myocardial injury.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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