Anti-EAAT1 Rabbit mAb [19D38]

Protein A affinity purification

Excitatory amino-acid transporter-1

E aaT1 (Excitatory Amino Acid Transporter 1) is a transmembrane transporter protein belonging to the SLC1 glutamate transporter family, encoded by the SLC1A3 gene, and serves as a key regulator of glutamate homeostasis in the central nervous system (CNS). Highly and specifically expressed on the plasma membrane of astrocytes, E aaT1 efficiently uptakes extracellular glutamate, precisely controls glutamate concentration in synaptic clefts, prevents excitotoxicity induced by excessive glutamate accumulation, and maintains stable neural signal transduction in the CNS. It also regulates intracellular and extracellular ion balance, neuronal survival and oxidative stress responses. Downregulated expression or dysfunction of E aaT1 leads to glutamate accumulation, neuroinflammation and neuronal apoptosis, closely associated with epilepsy, cerebral ischemic injury and neurodegenerative diseases.

Cell membrane