Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-EEA1 Rabbit mAb [46A85]
抗EEA1兔单克隆抗体 [46A85]
Cat. No.
A52105
Clone No. 46A85
SynonymsEarly endosome antigen 1, EEA1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
162 kDa
Observed MW
162 kDa
Clonality
Monoclonal
Clone No.
46A85
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
EEA1
Protein Name
Early endosome antigen-1
Background
EEA1 (Early Endosome Antigen 1) is a landmark scaffold protein for intracellular vesicle trafficking, encoded by the EEA1 gene with a molecular weight of approximately 162 kDa, and serves as a specific biomarker of early endosomes. Ubiquitously expressed in eukaryotic cells and localized on early endosome membranes, EEA1 binds to Rab5 and phosphatidylinositol to mediate early endosome formation, fusion and substance sorting, regulating endocytic trafficking, receptor recycling, intracellular signal transduction and vesicle homeostasis. As a core component of the cellular endocytic and vesicle transport system, abnormal EEA1 expression disrupts intracellular material transport and signal transduction, impairs cell proliferation, metabolism and stress responses, and is closely correlated with tumor invasion, inflammatory injury and organelle dysfunction.
Localization
Endosome
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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