Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-eIF2α (phospho Ser51) Rabbit mAb [59H24]
抗eIF2α (phospho Ser51)兔单克隆抗体 [59H24]
Cat. No.
A52111
Clone No. 59H24
SynonymseIF2α (phospho Ser51), p-eIF2α(Ser51), eIF2-alpha, eIF-2α, p-eIF2α(S51)
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
36 kDa
Observed MW
36 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
59H24
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
EIF2S1
Protein Name
eIF2α (phospho Ser51)
Background
Phospho-eIF2α (Ser51) is a critical functional modification site of eIF2α and a hallmark of stress-induced translational inhibition in cells. The Ser51 residue is specifically phosphorylated by stress kinases including PERK, GCN2, PKR and HRI in response to ER stress, oxidative stress, viral infection and amino acid deprivation. Ser51 phosphorylation markedly suppresses the translational initiation activity of the eIF2 complex, blocks global protein synthesis, and selectively activates the translation of stress-responsive genes to initiate cellular protective responses. Abnormal Ser51 phosphorylation serves as a key indicator of excessive ER stress and cellular stress damage. Sustained eIF2α phosphorylation induces cell apoptosis, metabolic disorders and inflammatory imbalance, extensively participating in the pathological progression of tumors, neurodegeneration and metabolic diseases.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:100-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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