Anti-ERK1/2 Rabbit mAb [11H71]

Protein A affinity purification

Mitogen-activated protein kinase-3 /-1

ERK1/2 (Extracellular Regulated Protein Kinases 1/2) are core isoforms of the MAPK serine/threonine kinase family, encoded by MAPK3 and MAPK1 genes respectively, and function as pivotal effector kinases of the canonical Ras-Raf-MEK-ERK signaling pathway. Ubiquitously expressed in various tissues and cells, ERK1/2 responds to diverse extracellular stimuli including growth factors, cytokines and stress signals. Upon cascade phosphorylation activation, ERK1/2 translocates to the nucleus to regulate downstream target gene transcription, governing fundamental biological processes such as cell proliferation, differentiation, survival, migration, metabolism and inflammatory responses. Sustained aberrant activation of ERK1/2 is a major driver of malignant tumor proliferation, fibrosis progression, chronic inflammation and metabolic disorders, making it a core research hotspot in life science and oncology.

Cytoplasm, Nucleus