Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Ezrin Rabbit mAb [72C43]
抗Ezrin兔单克隆抗体 [72C43]
Cat. No.
A52114
Clone No. 72C43
SynonymsEzrin, EZR, ERM protein family member, ezrin-radixin-moesin protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
69 kDa
Observed MW
80 kDa
Clonality
Monoclonal
Clone No.
72C43
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
EZR
Protein Name
Ezrin
Background
Ezrin is a core member of the ERM (Ezrin-Radixin-Moesin) actin cross-linking protein family encoded by the EZR gene, serving as a key scaffold protein linking the cell membrane and cytoskeleton. Ubiquitously expressed in epithelial cells, mesenchymal cells and other cell types, Ezrin is mainly localized in the cortical membrane region. It binds membrane receptors and actin cytoskeleton to maintain cell morphology, membrane stability and cell polarity, and regulates cell adhesion, migration, invasion and signal transduction. Abnormal Ezrin activation causes cytoskeletal remodeling disorder, reduced cell adhesion and enhanced migratory and invasive capacities, acting as a critical regulator of tumor metastasis, epithelial-mesenchymal transition and tissue remodeling dysfunction. It is aberrantly overexpressed in various malignant tumors and closely correlated with tumor prognosis.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:4000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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