Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-FAK Rabbit mAb [89G90]
抗FAK兔单克隆抗体 [89G90]
Cat. No.
A52115
Clone No. 89G90
SynonymsFAK, FAK1, PTK1, pp125FAK, focal adhesion protein tyrosine kinase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
119 kDa
Observed MW
119 kDa
Clonality
Monoclonal
Clone No.
89G90
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
PTK2
Protein Name
Focal adhesion kinase
Background
FAK (Focal Adhesion Kinase) is a key non-receptor tyrosine kinase encoded by the PTK2 gene, functioning as a central signaling hub for cell adhesion, migration and extracellular matrix signal transduction. Ubiquitously expressed in various cells and enriched at focal adhesion sites, FAK responds to cell-extracellular matrix adhesion signals and activates downstream signaling cascades including PI3K, ERK and Src via autophosphorylation, regulating cell adhesion, migration, proliferation, survival, invasion and cytoskeletal remodeling. Aberrant FAK activation and overexpression disrupt cellular adhesion homeostasis, promote tumor invasion, metastasis, malignant proliferation and drug resistance, and participate in tissue fibrosis and inflammatory repair disorders, making it a promising target for tumor targeted therapy.
Localization
Cytoplasm
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:400-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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