Anti-Fas Rabbit mAb [91A85]

Protein A affinity purification

Fas cell surface death receptor

Fas (Apoptosis-Related Factor) is a type I transmembrane receptor protein belonging to the tumor necrosis factor receptor superfamily, encoded by the FAS gene, and serves as a core receptor regulating the extrinsic apoptotic pathway. Ubiquitously expressed in most human tissues and cells, Fas trimerizes upon binding to its ligand FasL, recruits intracellular adaptor proteins to initiate caspase cascade reactions, and rapidly activates extrinsic apoptosis, participating in immune homeostasis maintenance, abnormal cell clearance and tissue developmental remodeling. Downregulated expression or functional inactivation of Fas leads to apoptosis escape, promoting tumor cell survival, immune evasion and autoimmune diseases. Dysregulated Fas expression is a critical pathological feature of tumors, chronic inflammation and immune disorders.

Cell membrane