Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Fibrillarin Rabbit mAb [20E67]
抗Fibrillarin兔单克隆抗体 [20E67]
Cat. No.
A52117
Clone No. 20E67
SynonymsFibrillarin, FBL1, NOP2, Nop2, fibrillarin homolog, pre-ribosomal protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
34 kDa
Observed MW
34 kDa
Clonality
Monoclonal
Clone No.
20E67
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
FBL
Protein Name
Fibrillarin
Background
Fibrillarin is a core component of small nucleolar ribonucleoproteins encoded by the FBL gene and serves as a classic functional biomarker of eukaryotic nucleoli. Specifically localized in the nucleolus, Fibrillarin primarily participates in rRNA transcription, 2'-O-ribose methylation modification, pre-rRNA processing and ribosome assembly and maturation, dominates cellular ribosome biogenesis, and regulates cell proliferation, protein synthesis and cell cycle progression. Fibrillarin expression level directly reflects nucleolar activity and cell proliferative status. Its aberrant overexpression is frequently observed in rapidly proliferating tumor cells and closely correlated with malignant proliferation and poor prognosis. It is also a classic marker for nucleolar structure labeling and cell proliferation activity detection.
Localization
Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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