Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-FGFR1 Rabbit mAb [52C21]
抗FGFR1兔单克隆抗体 [52C21]
Cat. No.
A52118
Clone No. 52C21
SynonymsFGFR1, BEK, CD328, CDw328, FGFBR, bFGF receptor, KGFR
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
91 kDa
Observed MW
145 kDa
Clonality
Monoclonal
Clone No.
52C21
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
FGFR1
Protein Name
Fibroblast growth factor receptor-1
Background
FGFR1 (Fibroblast Growth Factor Receptor 1) is an important isoform of the receptor tyrosine kinase family encoded by the FGFR1 gene, acting as a core transmembrane receptor of the FGF signaling pathway. Ubiquitously expressed in embryonic and adult tissues, FGFR1 binds fibroblast growth factors (FGFs) to activate intracellular tyrosine kinase domains and trigger downstream signaling cascades including Ras/MAPK and PI3K/Akt, regulating cell proliferation, differentiation, migration, angiogenesis, embryonic development and tissue repair. Aberrant FGFR1 amplification, mutation or sustained activation causes excessive pathway activation, driving tumor proliferation, invasion, angiogenesis, fibrosis and developmental malformations. It is a core therapeutic target for multiple solid tumors and proliferative diseases.
Localization
Cell membrane
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:100-1:200
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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