Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-FOXO3A (phospho Ser253) Rabbit mAb [87G30]
抗FOXO3A (phospho Ser253)兔单克隆抗体 [87G30]
Cat. No.
A52122
Clone No. 87G30
SynonymsFOXO3A (phospho Ser253), p-FOXO3A(Ser253), FKHRL1, FOXO3A, p-FOXO3(S253)
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
71 kDa
Observed MW
97 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
87G30
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
FOXO3
Protein Name
FOXO3A (phospho Ser253)
Background
Phosphorylated FOXO3A (Ser253) is an active modified form of Forkhead Box Protein O3A, belonging to the forkhead box protein family and widely existing in human tissue cells. It coregulates cell apoptosis, oxidative stress, aging process and tumor progression. Phosphorylation modification at the Ser253 site of FOXO3A is a key mechanism for its functional activation, which mediates the transcriptional expression of downstream antioxidant and pro-apoptotic genes, eliminating intracellular oxidative damage and inhibiting abnormal cell proliferation. Excessive or deficient phosphorylation at this site causes FOXO3A functional disorder, blocking cell apoptosis, accumulating oxidative stress and accelerating cell senescence, ultimately promoting the progression of ovarian cancer, lung cancer and degenerative diseases.
Localization
Cytoplasm
Research Area
肿瘤免疫
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。