Anti-GCLM Rabbit mAb [84C16]

Protein A affinity purification

Glutamate-cysteine ligase regulatory subunit

GCLM (Glutamate-Cysteine Ligase Modifier Subunit) is a regulatory subunit protein of the key glutathione synthetase family, widely expressed in metabolically active human tissues such as liver, kidney and lung. It coregulates endogenous glutathione synthesis, oxidative stress defense and cellular antioxidant homeostasis. By binding to the GCLC catalytic subunit, GCLM regulates the overall activity of glutamate-cysteine ligase, mediates the synthesis of glutathione, a key endogenous antioxidant, and eliminates intracellular reactive oxygen species to reduce oxidative damage. Downregulated expression or dysfunction of GCLM leads to insufficient glutathione synthesis, decreased antioxidant capacity and accumulated oxidative damage, further inducing liver injury, pulmonary fibrosis, tumors and neurodegenerative diseases.

Cytoplasm