Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Glutaminase C Rabbit mAb [34G18]
抗Glutaminase C兔单克隆抗体 [34G18]
Cat. No.
A52132
Clone No. 34G18
SynonymsGlutaminase C, GLS1-C, GLS, KGA, kidney-type glutaminase, glutaminase C
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
68 kDa
Observed MW
55-65 kDa
Clonality
Monoclonal
Clone No.
34G18
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
GLS1
Protein Name
Glutaminase-1, kidney isoform (Glutaminase-C)
Background
Glutaminase C (GAC) is a spliced subtype protein of the key glutamine metabolic enzyme family, mainly expressed in rapidly proliferating tumor cells and metabolically active tissue cells. It coregulates cellular glutamine catabolism, energy synthesis, tumor cell proliferation and microenvironment regulation. GAC efficiently catalyzes the hydrolysis of glutamine into glutamate, providing sufficient energy and synthetic raw materials for tumor cells to support infinite proliferation, invasion and metastasis. Abnormally overexpressed in various malignant tumors, GAC acts as a core driver of tumor glutamine metabolic reprogramming, and its excessive activation promotes tumor malignant progression, drug resistance and metabolic disorders.
Localization
Mitochondrion
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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