Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Glutamine Synthetase Rabbit mAb [53G73]
抗Glutamine Synthetase兔单克隆抗体 [53G73]
Cat. No.
A52133
Clone No. 53G73
SynonymsGlutamine Synthetase, GLUL, GS, GLNS, glutamine synthetase, glutamate-ammonia ligase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
42 kDa
Observed MW
42 kDa
Clonality
Monoclonal
Clone No.
53G73
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
GLUL
Protein Name
Glutamate-ammonia ligase (Glutamine synthetase)
Background
Glutamine Synthetase (GS) is a core member of the key nitrogen metabolic synthetase family, widely expressed in human liver, brain, muscle and tumor tissues. It coregulates in vivo glutamine synthesis, nitrogen metabolic balance, cell proliferation and neural homeostasis. GS catalyzes the synthesis of glutamine from glutamate and ammonia, maintains nitrogen metabolic balance, provides key raw materials for cell growth and protein synthesis, and participates in neurotransmitter metabolism and tissue repair. Abnormal overexpression of GS remodels cellular metabolic patterns, promotes tumor cell proliferation, migration and immune escape, and exerts oncogenic effects in liver cancer and glioma, while GS deficiency leads to nitrogen metabolism disorder and neurological abnormalities.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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