Anti-GM130 Rabbit mAb [26F07]

Protein A affinity purification

Golgi matrix protein-130

GM130 is a core structural protein of the Golgi matrix protein family, localized in the cis-Golgi vesicles of eukaryotic cells and widely expressed in various human normal and tumor cells. It coregulates Golgi structure maintenance, cellular vesicle transport, protein modification and sorting, and cell cycle regulation. GM130 stabilizes the morphological structure of the Golgi apparatus, regulates intracellular protein transport and glycosylation modification, and ensures normal cellular material metabolism and signal transduction. Abnormal expression or deletion of GM130 causes Golgi structural disorder, vesicle transport dysfunction and protein sorting abnormality, further leading to cell proliferation disorder and apoptosis imbalance, and promoting tumor invasion, metastasis and fibrotic disease progression.

Endosome