Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Glucocorticoid Receptor Rabbit mAb [80H93]
抗Glucocorticoid Receptor兔单克隆抗体 [80H93]
Cat. No.
A52137
Clone No. 80H93
SynonymsGlucocorticoid Receptor, GR, GR, NR3C1, glucocorticoid receptor alpha, glucocorticoid receptor
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
85 kDa
Observed MW
94 kDa
Clonality
Monoclonal
Clone No.
80H93
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NR3C1
Protein Name
Glucocorticoid receptor
Background
Glucocorticoid Receptor (GR) is a transcriptional regulatory protein of the nuclear receptor superfamily, widely expressed in various human tissue cells. It coregulates systemic inflammatory immune response, glucose and lipid metabolism, cell proliferation and apoptosis, and stress response. After specifically binding to glucocorticoids, GR translocates into the nucleus to regulate the transcription of downstream inflammation and metabolism-related target genes, inhibit excessive inflammatory responses, adjust metabolic balance and suppress abnormal cell proliferation. Functional defects, abnormal expression or signaling disorder of GR lead to uncontrolled inflammation, metabolic disorder and immune imbalance, inducing autoimmune diseases, metabolic syndrome, tumors and chronic inflammatory diseases.
Localization
Cytoplasm
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:1000-1:4000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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