Anti-Cleaved-N-terminal GSDMD Rabbit mAb [63A06]

Protein A affinity purification

Cleaved N-terminal fragment of Gasdermin-D

Cleaved N-terminal GSDMD is an active cleaved fragment of GSDMD belonging to the Gasdermin protein family, mainly expressed in pyroptotic immune cells and lesion cells. It coregulates pyroptosis pathway activation, inflammatory factor release and innate immune response. GSDMD is cleaved by inflammatory caspases to release active N-terminal fragments, which locate on the cell membrane to form membrane pores, mediate cell pyroptosis and lysis, and promote the massive release of inflammatory factors such as IL-1β and IL-18 to amplify local inflammatory responses. Abnormal activation of this target causes excessive pyroptosis and inflammatory storm, inducing sepsis, autoimmune diseases, inflammatory organ damage and abnormal tumor microenvironment inflammation.

Cell membrane