Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-GSK3β (phospho Ser9) Rabbit mAb [95E14]
抗GSK3β (phospho Ser9)兔单克隆抗体 [95E14]
Cat. No.
A52140
Clone No. 95E14
SynonymsGSK3β (phospho Ser9), p-GSK-3β(Ser9), GSK-3beta, glycogen synthase kinase 3 beta, p-GSK3beta(S9)
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
46 kDa
Observed MW
46 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
95E14
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
GSK3B
Protein Name
GSK3β (phospho Ser9)
Background
Phosphorylated GSK3β (Ser9) is an inactivated modified form of Glycogen Synthase Kinase 3β, belonging to the serine/threonine kinase family and widely existing in human cells. It coregulates glucose metabolism, cell apoptosis, inflammatory response, tumorigenesis and neural development. Phosphorylation modification at the Ser9 site of GSK3β inhibits its kinase activity, blocks downstream pro-apoptotic, pro-inflammatory and metabolism-inhibiting signaling pathways, and maintains cellular physiological homeostasis. Abnormally decreased phosphorylation level at this site leads to sustained GSK3β activation, causing glucose metabolism disorder, nerve cell apoptosis and excessive inflammation, and promoting tumor proliferation, metastasis, Alzheimer's disease and metabolic disease progression. Excessively increased phosphorylation causes abnormal cell proliferation.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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