Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-GRP78/BiP Rabbit mAb [57E30]
抗GRP78/BiP兔单克隆抗体 [57E30]
Cat. No.
A52173
Clone No. 57E30
SynonymsGRP78/BiP, GRP78, BiP, HSP72, HSP70 family member 5
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
72 kDa
Observed MW
78 kDa
Clonality
Monoclonal
Clone No.
57E30
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
HSPA5
Protein Name
Glucose-regulated protein 78 kDa
Background
GRP78/BiP (Glucose-regulated protein 78 / Binding immunoglobulin protein) is a member of the HSP70 heat-shock protein family, predominantly localized in the endoplasmic reticulum (ER) lumen. It acts as a central ER molecular chaperone responsible for folding and assembly of nascent polypeptides, as well as recognition and disposal of misfolded proteins. Its expression is strongly induced under ER stress triggered by hypoxia, oxidative injury and calcium disturbance to mitigate protein burden and promote cell survival. GRP78/BiP also modulates calcium homeostasis and lipid metabolism. Dysregulated up-regulation of GRP78/BiP drives tumor proliferation, metastasis and drug resistance, and is observed in neurodegenerative and metabolic disorders.
Localization
Endoplasmic Reticulum
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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