Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Hexokinase II Rabbit mAb [21E02]
抗Hexokinase II兔单克隆抗体 [21E02]
Cat. No.
A52178
Clone No. 21E02
SynonymsHexokinase II, HK-II, HKII, Type II hexokinase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
102 kDa
Observed MW
102 kDa
Clonality
Monoclonal
Clone No.
21E02
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
HK2
Protein Name
Hexokinase-2
Background
Hexokinase II (HK2) is a glycolytic enzyme of hexokinase family, localized in cytoplasm and capable of associating with outer mitochondrial membrane. It catalyzes glucose phosphorylation to generate glucose-6-phosphate, representing the rate-limiting first step of glycolysis. HK2 rewires cellular metabolism to boost glycolytic flux for rapid cell proliferation. Markedly up-regulated in diverse cancers, HK2 drives Warburg effect and facilitates tumor growth and anti-apoptosis. Its mitochondrial-bound pool cross-talks glycolysis with mitochondrial apoptotic signaling.
Localization
Mitochondrion
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:400
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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