50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
154 kDa
Observed MW
200 kDa
Clonality
Monoclonal
Clone No.
95A38
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
IGF1R
Protein Name
Insulin-like growth factor-1 receptor
Background
IGF-1 Receptor (Insulin-like growth factor 1 receptor, IGF-1R) is a receptor tyrosine kinase (RTK) family transmembrane glycoprotein at cell surface. Upon binding IGF-1 or IGF-2 ligands, it triggers downstream PI3K-AKT and MAPK cascades to govern cell proliferation, survival, differentiation and metabolism. IGF-1R signaling supports embryonic development and tissue homeostasis. Pathological hyper-activation fuels tumor proliferation, metastasis and therapeutic resistance.