Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-IL18 Rabbit mAb [85H64]
抗IL18兔单克隆抗体 [85H64]
Cat. No.
A52185
Clone No. 85H64
SynonymsIL18, IL-18, IGIF, IL-1 gamma, CRF-45
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
22 kDa
Observed MW
22 kDa
Clonality
Monoclonal
Clone No.
85H64
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
IL18
Protein Name
Interleukin-18
Background
IL-18 (Interleukin-18) belongs to IL-1 pro-inflammatory cytokine superfamily. It is synthesized as pro-IL-18 in macrophages and epithelial cells, and mature bioactive IL-18 is liberated after inflammasome-dependent cleavage. IL-18 potently stimulates IFN-γ secretion and promotes Th1-type immunity, augmenting cytotoxic function of NK and T-cells. It is critical for anti-pathogen defense, yet aberrant over-secretion contributes to autoimmunity, chronic inflammation and tissue injury. IL-18 exhibits dual roles in cancer: it can promote anti-tumor immunity or exacerbate tumor progression context-dependently.
Localization
Secreted
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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