Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-IRF3 Rabbit mAb [26D44]
抗IRF3兔单克隆抗体 [26D44]
Cat. No.
A52194
Clone No. 26D44
SynonymsIRF3, IRF-3, ISGF3 gamma, NF-IL6
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
47 kDa
Observed MW
55 kDa
Clonality
Monoclonal
Clone No.
26D44
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
IRF3
Protein Name
Interferon regulatory factor-3
Background
IRF3 (Interferon regulatory factor 3) belongs to IRF transcription-factor family and resides in cytoplasm under resting conditions. It governs innate immune transcriptional programs: upon activation of cytosolic pattern-recognition receptors, IRF3 undergoes phosphorylation and dimerization, translocates into nucleus and triggers transcription of type-I interferons and antiviral genes. IRF3 is central for antiviral innate immunity; its dysfunction impairs host antiviral defense. Aberrant IRF3 activation contributes to inflammatory pathologies.
Localization
Cytoplasm, Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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