Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-IRS-1 Rabbit mAb [23D04]
抗IRS-1兔单克隆抗体 [23D04]
Cat. No.
A52195
Clone No. 23D04
SynonymsIRS-1, CAIR-1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
131 kDa
Observed MW
180 kDa
Clonality
Monoclonal
Clone No.
23D04
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
IRS1
Protein Name
Insulin receptor substrate-1
Background
IRS-1 (Insulin receptor substrate-1) is a cytoplasmic adaptor of IRS protein family. It transduces downstream signals from insulin and IGF-1 receptors. Receptor-triggered tyrosine phosphorylation of IRS-1 recruits effectors including PI3K and initiates PI3K-AKT cascade to regulate glucose metabolism, cell proliferation and survival. Serine phosphorylation promotes IRS-1 turnover and signal desensitization, strongly linked to insulin resistance. Dysregulated IRS-1 signaling underlies metabolic disorders and tumor progression.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:400-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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