50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
18 kDa
Observed MW
18 kDa
Clonality
Monoclonal
Clone No.
75A64
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
ISG15
Protein Name
Interferon-stimulated gene-15
Background
ISG15 (Interferon-stimulated gene 15) is a ubiquitin-like modifier whose expression is potently induced by type-I interferons. It mediates ISGylation, a post-translational modification that covalently conjugates target proteins to alter their stability, localization and function for host antiviral innate defense. ISG15 restricts replication of diverse viruses; unconjugated free ISG15 exerts cytokine-like activities to tune immune-cell responses. Dysregulated ISG15 is associated with viral infection, inflammation and cancer.