Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-IκBα Rabbit mAb [85G01]
抗IκBα兔单克隆抗体 [85G01]
Cat. No.
A52197
Clone No. 85G01
SynonymsIκBα, IκB-α, I Kappa B alpha, NFKB-I, MAD-3
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
36 kDa
Observed MW
36 kDa
Clonality
Monoclonal
Clone No.
85G01
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NFKBIA
Protein Name
NF-Kappa-B inhibitor alpha
Background
IκB-α (NF-κB inhibitor alpha) is a cytoplasmic anchoring protein of IκB inhibitor family. It negatively controls NF-κB transcription factor: under basal conditions, IκB-α sequesters NF-κB dimers in cytoplasm and blocks nuclear transcriptional activity. Inflammatory triggers induce IκB-α phosphorylation, ubiquitination and proteasomal degradation, liberating NF-κB for nuclear import and pro-inflammatory-gene transcription. De-novo synthesized IκB-α provides negative feedback to terminate NF-κB activity. IκB-α degradation serves as a hallmark of NF-κB pathway activation.
Localization
Cytoplasm
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:200-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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