LRP1 (Low-density lipoprotein receptor-related protein 1) is a transmembrane receptor of LDL-receptor superfamily, broadly expressed across cell types. It mediates endocytic clearance of diverse ligands including lipoproteins, protease-inhibitor complexes and growth factors, and also participates in signal transduction. LRP1 contributes to lipid homeostasis, protein turnover and vascular biology. It exerts context-dependent pro- or anti-tumor effects by modulating proliferation and migration.