Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-cGAS Rabbit mAb [55H80]
抗cGAS兔单克隆抗体 [55H80]
Cat. No.
A52211
Clone No. 55H80
SynonymscGAS, Cyclic GMP-AMP synthase
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
62 kDa
Observed MW
62 kDa
Clonality
Monoclonal
Clone No.
55H80
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CGAS
Protein Name
Cyclic GMP-AMP synthase
Background
cGAS (Cyclic GMP-AMP synthase) is a cytosolic pattern-recognition receptor of nucleotidyltransferase family. Upon binding abnormal cytoplasmic DNA from invading pathogens or damaged host nuclei, cGAS synthesizes second-messenger cGAMP to activate STING-dependent signaling, triggering type-I interferon and pro-inflammatory cytokine production for innate immune defense. cGAS-STING axis mediates anti-pathogen and anti-tumor immunity, while its hyper-activation drives auto-inflammatory disorders.
Localization
Cytoplasm
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:100-1:500
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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