Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-MEK1/2 Rabbit mAb [94B38]
抗MEK1/2兔单克隆抗体 [94B38]
Cat. No.
A52214
Clone No. 94B38
SynonymsMEK1/2, MEK1, MEK2, MAP2K1, MAP2K2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
44 kDa
Clonality
Monoclonal
Clone No.
94B38
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
MAP2K1, MAP2K2
Protein Name
Mitogen-activated protein kinase kinase-1/2
Background
MEK1/2 (Mitogen-activated protein kinase kinase 1/2) are cytoplasmic dual-specificity kinases of MAPKK family. They act downstream of RAS-RAF: activated via RAF-mediated phosphorylation, MEK1/2 in turn phosphorylate and activate ERK1/2 to propagate RAS-RAF-MEK-ERK signaling cascade governing cell proliferation, differentiation and survival. Sustained pathological MEK activation fuels tumor progression, and MEK inhibitors constitute major targeted anti-cancer therapeutics.
Localization
Cytoplasm
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:500-1:2000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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