50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
90 kDa
Observed MW
90 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
79H17
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
RPS6KA5
Protein Name
MSK1 (phospho Ser360)
Background
MSK1 (Phospho Ser360) (Mitogen- and stress-activated kinase 1, Ser360 phosphorylated form) belongs to RSK/MSK nuclear-kinase family. Ser360 phosphorylation is a regulatory post-translational modification of MSK1. Triggered by upstream ERK/p38 MAPK signaling, Ser360 phosphorylation facilitates full MSK1 activation. Active MSK1 translocates into nucleus and phosphorylates histone substrates and CREB to drive stress- and inflammation-associated gene transcription. Phospho-MSK1 (Ser360) serves as a specific readout for MSK1-pathway activation.