Anti-MSK1 (phospho Ser360) Rabbit mAb [79H17]

抗MSK1 (phospho Ser360)兔单克隆抗体 [79H17]

Cat. No. A52222 Clone No. 79H17

SynonymsMSK1 (phospho Ser360), p-MSK1(Ser360)

Host species Rabbit
Reactivity Human, Mouse, Rat
Applications WB, IP, IF, ELISA

详细信息 Product Information

Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
90 kDa
Observed MW
90 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
79H17
Isotype
IgG, Kappa

抗原与靶点信息 Antigen & Target Information

Gene Name
RPS6KA5
Protein Name
MSK1 (phospho Ser360)
Background
MSK1 (Phospho Ser360) (Mitogen- and stress-activated kinase 1, Ser360 phosphorylated form) belongs to RSK/MSK nuclear-kinase family. Ser360 phosphorylation is a regulatory post-translational modification of MSK1. Triggered by upstream ERK/p38 MAPK signaling, Ser360 phosphorylation facilitates full MSK1 activation. Active MSK1 translocates into nucleus and phosphorylates histone substrates and CREB to drive stress- and inflammation-associated gene transcription. Phospho-MSK1 (Ser360) serves as a specific readout for MSK1-pathway activation.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
数据库链接
物种 Organism基因 IDSwissProt
Human 9252 O75582
Mouse 73086 Q8C050

实验信息 Product Usage & Documents

推荐稀释比 Recommended Dilution

WB
1:1000-1:5000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议,实际需按样本类型与显色体系优化。

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