Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-mTOR (phospho Ser2448) Rabbit mAb [07F22]
抗mTOR (phospho Ser2448)兔单克隆抗体 [07F22]
Cat. No.
A52223
Clone No. 07F22
SynonymsmTOR (phospho Ser2448), p-mTOR(Ser2448), mTOR, FRAP1, RAFT1, FRAP
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
289 kDa
Observed MW
250 kDa
Modification
Phospho
Clonality
Monoclonal
Clone No.
07F22
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
MTOR
Protein Name
mTOR (phospho Ser2448)
Background
mTOR (mammalian target of rapamycin) is a serine/threonine kinase belonging to the PI3K-related kinase family. It functions in two complexes, mTORC1 and mTORC2, governing cell proliferation, metabolism, autophagy and protein synthesis. Ser2448 and Ser2481 are two critical phosphorylation sites on mTOR. Phosphorylation at Ser2448 is predominantly mediated by AKT and serves as an activation marker of mTORC1 upon growth factor stimulation. Ser2481 is an autophosphorylation site reflecting intrinsic mTOR kinase activity and exists in both mTORC1 and mTORC2.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:500-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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