Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-MUC2 Rabbit mAb [33A51]
抗MUC2兔单克隆抗体 [33A51]
Cat. No.
A52226
Clone No. 33A51
SynonymsIntestinal mucin, MUC2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
551 kDa
Observed MW
140-170 kDa
Clonality
Monoclonal
Clone No.
33A51
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
MUC2
Protein Name
Mucin-2
Background
MUC2 (Mucin-2) is a secreted mucin family protein responsible for intestinal mucus barrier formation and mucosal protection. Synthesized and secreted by goblet cells, MUC2 constitutes the major component of intestinal mucus layers, building a bilayer mucus structure that separates epithelium from gut microbiota and prevents bacterial invasion. Heavy O-linked glycosylation dominates its biochemical properties. Defective expression or structural alteration of MUC2 disrupts intestinal barrier and contributes to inflammatory bowel disease and enteric infection. Down-regulated MUC2 is observed in colon carcinoma and acts as a progression biomarker.
Localization
Secreted
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:1000-1:4000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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