Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-N-Cadherin Rabbit mAb [10E01]
抗N-Cadherin兔单克隆抗体 [10E01]
Cat. No.
A52230
Clone No. 10E01
SynonymsN-Cadherin, N-cadherin, CHC2
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
125 kDa
Observed MW
130 kDa
Clonality
Monoclonal
Clone No.
10E01
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
CDH2
Protein Name
Neural cadherin
Background
N-cadherin (N-cadherin, cadherin-2) belongs to type-I membrane protein of cadherin superfamily and mediates Ca2+-dependent cell-cell adhesion and cell migration. Its extracellular domain mediates homophilic adhesion in calcium-dependent manner; intracellular tail recruits catenins to link actin cytoskeleton. N-cadherin is abundant in neural, mesenchymal and cardiac tissues. It participates in neurodevelopment, cardiogenesis and mesenchymal cell interaction. During epithelial-mesenchymal transition (EMT), N-cadherin is up-regulated to replace E-cadherin and enhances tumor migratory and invasive capacity, serving as canonical EMT biomarker. Aberrant N-cadherin correlates with poor clinical prognosis; its adhesive activity dynamically controls cell motility and tissue morphogenesis.
Localization
Cell membrane
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:500-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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