Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-NDUFS3 Rabbit mAb [72B87]
抗NDUFS3兔单克隆抗体 [72B87]
Cat. No.
A52231
Clone No. 72B87
SynonymsNDUFS3, B17, PSAD, NDUFS3
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
30 kDa
Observed MW
30 kDa
Clonality
Monoclonal
Clone No.
72B87
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NDUFS3
Protein Name
NADH-ubiquinone oxidoreductase core subunit S3
Background
NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3) is a nuclear-encoded core subunit of mitochondrial Respiratory Complex I, responsible for Complex I assembly and oxidative phosphorylation. Localized to inner mitochondrial membrane, NDUFS3 acts as core component of NADH dehydrogenase complex, initiating electron transport and building proton gradient for ATP production. Mutation or depletion of NDUFS3 causes severe Complex-I deficiency and mitochondrial encephalopathy. Oxidative stress reduces NDUFS3 abundance and aggravates ROS accumulation. Altered NDUFS3 expression drives metabolic reprogramming in cancers. NDUFS3 protein level mirrors Complex-I integrity, and protein degradation occurs upon mitochondrial damage.
Localization
Mitochondrion
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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