Anti-Neuropilin 1 Rabbit mAb [45H56]

Protein A affinity purification

Neuropilin-1

Neuropilin-1 (NRP1, neuropilin-1) is a non-tyrosine-kinase transmembrane co-receptor family protein regulating angiogenesis, axon guidance and cell migration. With multi-domain extracellular region, NRP1 functions as VEGF co-receptor to amplify VEGFR signaling and promote endothelial proliferation and migration; meanwhile it binds semaphorins to mediate axon guidance. It is expressed in endothelial cells, neurons and multiple tumor cell types. Physiologically NRP1 controls vascular patterning and neural projection. In tumor microenvironment NRP1 overexpression augments angiogenic signals and supports neovascularization, invasion and metastasis. Devoid of intracellular kinase domain, NRP1 transduces signals via partnering receptors and represents a potential anti-angiogenic therapeutic target.

Cell membrane