Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Neurofilament heavy polypeptide Rabbit mAb [37F08]
抗Neurofilament heavy polypeptide兔单克隆抗体 [37F08]
Cat. No.
A52234
Clone No. 37F08
SynonymsNeurofilament heavy polypeptide, NF-H, NF-H, Neurofilament high molecular weight protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
110 kDa
Observed MW
180-200 kDa
Clonality
Monoclonal
Clone No.
37F08
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NEFH
Protein Name
Neurofilament heavy chain
Background
NEFH (Neurofilament heavy polypeptide, neurofilament heavy chain) belongs to intermediate-filament cytoskeletal protein family and builds axonal skeleton to sustain axonal caliber and structural stability in mature neurons. Highly specific for mature neurons, NEFH polymerizes with NF-L and NF-M to form neurofilament networks filling axonal cytoplasm and determining axon diameter for proper nerve impulse conduction. Abundant phosphorylation sites locate at C-terminal tail and modulate neurofilament assembly. Upon nerve injury or neurodegeneration, NEFH degrades and leaks into cerebrospinal fluid; axonal lesions cause mis-localization of NEFH.
Localization
Cytoplasm
Research Area
神经科学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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