Anti-NF-κB p65 Rabbit mAb [87D06]

Protein A affinity purification

NF-Kappa-B subunit p65

RELA (NF-κB p65, RELA proto-oncogene, NF-κB subunit) belongs to NF-κB transcription-factor family and modulates inflammatory response, immunity, cell proliferation and apoptosis. As major functional subunit, p65 heterodimerizes with p50 and binds κB motifs on target promoters. In resting cells p65-p50 heterodimer is retained in cytoplasm by IκB. Upstream signaling triggers IκB degradation and permits p65 nuclear translocation for gene transactivation. It participates in innate immunity and cellular stress response. Sustained NF-κB activation drives inflammation, fibrosis and tumor progression. This total-p65 antibody detects overall protein abundance independent of phosphorylation status.

Cytoplasm, Nucleus