Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-NLRP3 Rabbit mAb [15D34]
抗NLRP3兔单克隆抗体 [15D34]
Cat. No.
A52239
Clone No. 15D34
SynonymsNLRP3, NALP3, Cryopyrin, PYPAF1, CIAS1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
118 kDa
Observed MW
115 kDa
Clonality
Monoclonal
Clone No.
15D34
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NLRP3
Protein Name
NLR family pyrin domain-containing-3
Background
NLRP3 (NLR family pyrin domain containing 3) is NOD-like receptor inflammasome family protein sensing intracellular danger signals and mediating NLRP3 inflammasome assembly. Cytosolic NLRP3 detects stimuli including ATP, crystalline particles and PAMPs, undergoes oligomerization, recruits ASC and pro-caspase-1 to build inflammasome complex. Activated caspase-1 cleaves pro-IL-1β and pro-IL-18 into mature pro-inflammatory cytokines and triggers pyroptosis. Dysregulated NLRP3 activation contributes to gout, autoinflammatory disorders, neuroinflammation and tumor-microenvironment inflammation. Full NLRP3 activity requires two-step control: transcriptional priming followed by secondary trigger signal to complete inflammasome assembly, which tightly restricts inflammatory magnitude.
Localization
Cytoplasm
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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