Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Notch1 Rabbit mAb [25A37]
抗Notch1兔单克隆抗体 [25A37]
Cat. No.
A52242
Clone No. 25A37
SynonymsNotch1, Notch-1, NOTCH-1, SPM-1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
273 kDa
Observed MW
120 kDa
Clonality
Monoclonal
Clone No.
25A37
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NOTCH1
Protein Name
Notch receptor-1
Background
Notch1 (Notch receptor 1) is Notch transmembrane receptor family protein mediating juxtacrine cell-cell communication to govern cell fate, proliferation and differentiation. Upon binding Jagged or Delta ligands on neighboring cells, its intracellular domain NICD is proteolytically cleaved and translocates into nucleus, where it interacts with RBP-Jκ to modulate target-gene transcription. Notch1 participates in embryogenesis, organogenesis and stem-cell fate determination. It displays context-dependent oncogenic or tumor-suppressive roles; constitutive activation drives malignancies such as T-ALL.
Localization
Cell membrane
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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