Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-NADPH oxidase 4 Rabbit mAb [43E85]
抗NADPH oxidase 4兔单克隆抗体 [43E85]
Cat. No.
A52243
Clone No. 43E85
SynonymsNADPH oxidase 4, NOX4, CYORC, RNOX4
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
67 kDa
Observed MW
67 kDa
Clonality
Monoclonal
Clone No.
43E85
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
NOX4
Protein Name
NADPH oxidase-4
Background
NOX4 (NADPH oxidase 4) belongs to NADPH oxidase family and catalyzes NADPH-dependent reactive oxygen species production. Predominantly localized at endoplasmic reticulum and mitochondria-associated membranes, NOX4 differs from other NOX isoforms by exhibiting constitutive enzymatic activity independent of cytosolic subunits, continuously generating H₂O₂. It contributes to signal transduction, apoptosis, fibrosis and vascular remodeling. Physiological ROS acts as second messenger; NOX4 up-regulation induces oxidative stress and promotes renal/pulmonary fibrosis, cardiovascular injury and tumor progression. NOX4 preferentially produces hydrogen peroxide rather than superoxide anion. Its expression is strongly induced by TGF-β and serves as key effector during fibrogenesis.
Localization
Cytoplasm
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
相关产品 Related Products
Anti-IL-1β Rabbit mAb [99F42]
WBIPIFELISA
Anti-Polycomb Protein SUZ12 Rabbit mAb [36G88]
WBIHCIPIFELISA
价格与规格
该产品暂未录入规格价格，请联系我们获取报价与现货情况。